Vitamin K epoxide reductase

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Vitamin K epoxide reductase
Identifiers
Symbol VKORC1
Alt. Symbols VKCFD2
Entrez 79001
HUGO 23663
RefSeq NM_024006
Other data
Locus Chr. 16 p11.2

Vitamin K epoxide reductase (VKOR) is an enzyme (EC 1.1.4.1) that reduces vitamin K after it has been oxidised in the carboxylation of glutamic acid. Its C1 subunit (VKORC1) is the target of anticoagulant warfarin.[1][2]

References

  1. ^ Li T, Chang CY, Jin DY, Lin PJ, Khvorova A, Stafford DW. Identification of the gene for vitamin K epoxide reductase. Nature 2004;427(6974):541-4. PMID 14765195.
  2. ^ Rost S, Fregin A, Ivaskevicius V, Conzelmann E, Hortnagel K, Pelz HJ, Lappegard K, Seifried E, Scharrer I, Tuddenham EG, Muller CR, Strom TM, Oldenburg J. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature 2004;427(6974):537-41. PMID 14765194.

See also

v • d • e
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1 NAD/NADP acceptor
1.1.2 cytochrome acceptor
1.1.3 oxygen acceptor
1.1.4 disulfide as acceptor
1.1.5 quinone/similar acceptor
1.1.99 other acceptors
v • d • e
Metabolism of vitamins, coenzymes, and cofactors
Vitamin A
Thiamine (B1)
Niacin (B3)
Folic acid (B9)
Vitamin C
Vitamin D
Vitamin K
Vitamin K epoxide reductase

Wikipedia content modification information:

  • This page was last modified on 30 May 2008, at 17:14.

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