Winterbottom's sign

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Winterbottom's sign - Swollen lymph nodes along back of neck in child with early trypanosomiasis

Winterbottom's sign is seen in the early phase of African trypanosomiasis, a disease caused by the parasites Trypanosoma brucei rhodiense and Trypanosoma brucei gambiense which is more commonly known as African sleeping sickness. Winterbottom's sign is the swelling of lymph nodes (lymphadenopathy) along the back of the neck, in the posterior cervical chain of lymph nodes, as trypanosomes travel in the lymphatic fluid and cause inflammation.

It may be suggestive of cerebral infection.1

Eponym

The name originates from Chris Winterbottom, a parasitoligst who first developed the diagnostic technique, which is now used across Africa, for surveying the migration of the disease from endemic areas of those with preclinical infections.

References

  1. ^ Ormerod WE (October 1991). "Hypothesis: the significance of Winterbottom's sign". J Trop Med Hyg 94 (5): 338–40. PMID 1942213. 
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Eponymous medical signs for infectious disease
Bacterial disease
Viral disease
Parasitic disease
Romana's sign · Schüffner's dots · Winterbottom's sign

Wikipedia content modification information:

  • This page was last modified on 9 August 2008, at 04:52.

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