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 Transmission electron micrograph of Wolbachia within an insect cell.
Credit:Public Library of Science / Scott O'Neill |
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Wolbachia is a genus of inherited bacteria which infects arthropod species, including a high proportion of insects. It is one of the world's most common parasitic microbes and is potentially the most common reproductive parasite in the biosphere. One study concludes that more than 16% of neotropical insect species carry this bacterium1 and as many as 25-70% of all insect species are estimated to be potential hosts.2
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History
The bacterium was first identified in 1924 by M. Hertig and S. B. Wolbach in Culex pipiens, a species of mosquito. Hertig formally described the genus 1936 as Wolbachia pipientis.3 There was little interest after the discovery until 1971 when it was discovered that Culex mosquito eggs were killed when the sperm of Wolbachia infected males fertilized infection-free eggs (Cytoplasmic incompatibility).4 It is today of considerable interest due to the nature of interactions and evolutionary consequences. It was discovered that Wolbachia makes males dispensable in 1990 by Richard Stouthamer of the University of Califonia, Riverside.5
Role in sexual differentiation of hosts
Within arthropods, Wolbachia is notable for significantly altering the reproductive capabilities of its hosts. These bacteria can infect many different types of organs, but are most notable for the infections of the testes and ovaries of their hosts.
Wolbachia are known to cause four different phenotypes:
- Male killing: death of infected males.
- Feminization: infected males develop as females or infertile pseudo-females.
- Parthenogenesis: reproduction of infected females without males. Some scientists have suggested that parthenogenesis may always be attributable to the effects of Wolbachia.6 An example of a Pathogenic species would be the Trichogramma wasp.5
- Cytoplasmic incompatibility: the inability of Wolbachia-infected males to successfully reproduce with uninfected females or females infected with another Wolbachia strain.
Several species are so dependent on Wolbachia that they are unable to reproduce effectively without the bacteria in their bodies.7
Wolbachia are present in mature eggs, but not mature sperm. Only infected females pass the infection on to their offspring. It is thought that the phenotypes caused by Wolbachia, especially cytoplasmic incompatibility, may be important in promoting speciation.89 Wolbachia can also cause misleading results in molecular cladistical analyses.10
Horizontal gene transfer and genomics
The first Wolbachia genome to be determined was that of one that infects Drosophila melanogaster flies11. This genome was sequenced at The Institute for Genomic Research in a collaboration between Jonathan Eisen and Scott O'Neill. The second Wolbachia genome to be determined was one that infects Brugia malayi nematodes12. Genome sequencing projects for several other Wolbachia strains are in progress. A complete copy of the Wolbachia genome sequence was found within the genome sequence of the fruit fly Drosophila ananassae and large segments were found in 7 other Drosophila species.13
In an application of DNA barcoding to the identification of species of Protocalliphora flies, it was found that several distinct morphospecies had identical cytochrome c oxidase I gene sequences, most likely through horizontal gene transfer by Wolbachia species as they jump across host species.14
Applications to human health
Outside of insects, Wolbachia infects a variety of isopod species, spiders, mites, and many species of filarial nematodes (a type of parasitic worm), including those causing onchocerciasis ("River Blindness") and elephantiasis in humans as well as heartworms in dogs. Not only are these disease-causing filarial infected with Wolbachia, but Wolbachia seem to play an inordinate role in these diseases. A large part of the pathogenicity of filarial nematodes is due to host immune response toward their Wolbachia. Elimination of Wolbachia from filarial nematodes generally results in either death or sterility.15 Consequently, current strategies for control of filarial nematode diseases include elimination of Wolbachia via the simple doxycycline antibiotic rather than far more toxic anti-nematode medications.16
The use of modified strains of Wolbachia to control mosquito populations has also been a topic of research.17
See also
References
- Werren J.H. (1997). "Biology of Wolbachia" (PDF). Annual Review of Entomology 42: 587–609. doi:. ISSN 0066-4170, http://www.rochester.edu/college/bio/labs/WerrenLab/My%20Papers/1997_Wolbach_AnRevEnt.pdf.
Footnotes
- ^ Werren, J.H.; Guo L, Windsor D. W. (1995). "Distribution of Wolbachia in neotropical arthropods". Proc. R. Soc. London Ser. B 262: 147–204.
- ^ Kozeka, Wieslaw J.; Ramakrishna U. Rao (2007). The Discovery of Wolbachia in Arthropods and Nematodes – A Historical Perspective. 5. pp. 1–14. doi:.
- ^ Hertig M & Wolbach SB (1924). "Studies on Rickettsia-like microorganisms in insects". Journal of Medical Research 44: 329–74.
- ^ Yen, J. H.; Barr, A. R. (1971). "New hypothesis of the cause of cytoplasmic incompatibility in Culex pipiens". Nature 232: 657–658. doi:.
- ^ a b Jonathan Knight (2001). "Meet the Herod Bug". Nature 421: 12-14.
- ^ Gerard J. Tortora, Berdell R. Funke, Cristine L. Case (2007). Microbiology: an introduction. Pearson Benjamin Cummings. ISBN 0805347909.
- ^ Werren, John H. (February 2003). "Invasion of the Gender Benders: by manipulating sex and reproduction in their hosts, many parasites improve their own odds of survival and may shape the evolution of sex itself" (Reprint). Natural History 112 (1): 58. ISSN 0028-0712. OCLC 1759475, http://findarticles.com/p/articles/mi_m1134/is_1_112/ai_97174198. Retrieved on 15 November 2008.
- ^ Zimmer, Carl (2001). "Wolbachia: A Tale of Sex and Survival". Science 292 (5519): 1093–5. doi:. ISSN 0036-8075. PMID 11352061, http://carlzimmer.com/articles/2001.php?subaction=showfull&id=1177558753&archive=&start_from=&ucat=4&.
- ^ Telschow A, Flor M, Kobayashi Y, Hammerstein P, Werren JH. (2007). "Wolbachia-induced unidirectional cytoplasmic incompatibility and speciation: mainland-island model". PLoS_ONE 2 (1): e701. doi:. ISSN (Electronic) 1932-6203 (Electronic).
- ^ Johnstone RA, Hurst GDD (1996). "Maternally inherited male-killing microorganisms may confound interpretation of mitochondrial DNA variability". Biological Journal of the Linnean Society 58 (4): 453–470. ISSN 0024-4066, http://www.ingentaconnect.com/content/ap/bj/1996/00000058/00000004/art00047.
- ^ Wu M, Sun LV, Vamathevan J, et al (2004). "Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements". PLoS Biol. 2 (3): E69. doi:. PMID 15024419, http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0020069&ct=1.
- ^ Foster J, Ganatra M, Kamal I, et al (2005). "The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode". PLoS Biol. 3 (4): e121. doi:. PMID 15780005, http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0030121.
- ^ Dunning Hotopp, J.C, Clark ME, Oliveira DC, Foster JM, Fischer P, Torres MC, Giebel JD, Kumar N, Ishmael N, Wang S, Ingram J, Nene RV, Shepard J, Tomkins J, Richards S, Spiro DJ, Ghedin E, Slatko BE, Tettelin H, Werren J.H. (2007). Widespread Lateral Gene Transfer from Intracellular Bacteria to Multicellular Eukaryotes, Science.
- ^ T.L. Whitworth, R.D. Dawson, H. Magalon, E. Baudry (2007) DNA barcoding cannot reliably identify species of the blowfly genus Protocalliphora (Diptera: Calliphoridae). Proceedings of the Royal Society B: 274: 1731-1739
- ^ Hoerauf A, Mand S, Fischer K, et al (2003). "Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production". Med. Microbiol. Immunol. 192 (4): 211–6. doi:. PMID 12684759.
- ^ Taylor MJ, Makunde WH, McGarry HF, Turner JD, Mand S, Hoerauf A (2005). "Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial". Lancet 365 (9477): 2116–21. doi:. PMID 15964448.
- ^ Xi, Zhiyong; Jeffry L. Dean, Cynthia Khoo, Stephen. L. Dobson (2005). "Generation of a novel Wolbachia infection in Aedes albopictus (Asian tiger mosquito) via embryonic microinjection". Insect Biochemistry and Molecular Biology 35: 903–910. doi:.
External links
- Virtual Museum of Bacteria
- Wolbachia research portal National Science Foundation
- "One Species' Genome Discovered Inside Another's -- Bacterial to Animal Gene Transfers Now Shown to be Widespread, with Implications for Evolution and Control of Diseases and Pests", University of Rochester (August 30, 2007). Retrieved on 27 November 2007.
- Wolbachia at the Encyclopedia of Life
- Howard Hughes Medical Institute High School Lab Series
Wikipedia content modification information:
- This page was last modified on 15 November 2008, at 15:54.
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