XCR1

This MedLibrary.org supplementary page on XCR1 is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

Chemokine (C motif) receptor 1
Identifiers
Symbols XCR1; CCXCR1; GPR5
External IDs OMIM: 600552 MGI: 1346338 HomoloGene: 21095
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2829 23832
Ensembl ENSG00000173578 ENSMUSG00000060509
Uniprot P46094 Q544D8
Refseq NM_001024644 (mRNA)
NP_001019815 (protein)		 NM_011798 (mRNA)
NP_035928 (protein)
Location Chr 3: 46.04 - 46.04 Mb Chr 9: 123.7 - 123.71 Mb
Pubmed search [1] [2]


The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2 (or lymphotactin-1 and -2).

XCR1 is also known as GPR5.

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.1

References

  1. ^ "Entrez Gene: XCR1 chemokine (C motif) receptor 1".

Further reading

  • Maghazachi AA (1999). "Intracellular signalling pathways induced by chemokines in natural killer cells.". Cell. Signal. 11 (6): 385–90. PMID 10400311. 
  • Gao JL, Kuhns DB, Tiffany HL, et al. (1993). "Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.". J. Exp. Med. 177 (5): 1421–7. PMID 7683036. 
  • Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors.". DNA Cell Biol. 14 (1): 25–35. PMID 7832990. 
  • Yoshida T, Imai T, Kakizaki M, et al. (1998). "Identification of single C motif-1/lymphotactin receptor XCR1.". J. Biol. Chem. 273 (26): 16551–4. PMID 9632725. 
  • Shan L, Qiao X, Oldham E, et al. (2000). "Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1.". Biochem. Biophys. Res. Commun. 268 (3): 938–41. doi:10.1006/bbrc.2000.2235. PMID 10679309. 
  • Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.". Cytogenet. Cell Genet. 87 (3-4): 265–8. PMID 10702689. 
  • Kurt RA, Bauck M, Harma S, et al. (2001). "Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo.". Cell. Immunol. 209 (2): 83–8. doi:10.1006/cimm.2001.1790. PMID 11446740. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Shinkai H, Morozumi T, Toki D, et al. (2005). "Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1.". Gene 349: 55–66. doi:10.1016/j.gene.2004.10.017. PMID 15777643. 
  • Lüttichau HR, Johnsen AH, Jurlander J, et al. (2007). "Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3.". J. Biol. Chem. 282 (24): 17794–805. doi:10.1074/jbc.M702001200. PMID 17403668. 

External links

 This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
G protein-coupled receptors, cytokine receptors: chemokine receptors
CC chemokine receptors
CXC chemokine receptors
Other
CCBP2 - CMKLR1 - CX3CR1 - XCR1

Wikipedia content modification information:

  • This page was last modified on 8 July 2008, at 04:09.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "XCR1".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.