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| Xanomeline | |
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| IUPAC name | 3-(4-hexoxy-1,2,5-thiadiazol-3-yl)-1-methyl-5,6-dihydro-2H-pyridine |
| Identifiers | |
| CAS number | 131986-45-3 |
| PubChem | |
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| Properties | |
| Molecular formula | C14H23N3OS |
| Molar mass | 281.42 g mol−1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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Xanomeline is a muscarinic agonist selective for the M1 subtype.1 It has recently been studied in Europe for the cognitive and negative symptoms of Schizophrenia, and there were robust associated improvements in verbal learning and short-term memory. 2
References
- ^ Farde L, Suhara T, Halldin C, et al (1996). "PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man". Dementia 7 (4): 187–95. PMID 8835881.
- ^ Am J Psychiatry. 2008 Aug;165(8):1033-9. Epub 2008 Jul 1. Links Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia.Shekhar A, Potter WZ, Lightfoot J, Lienemann J, Dubé S, Mallinckrodt C, Bymaster FP, McKinzie DL, Felder CC.
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Wikipedia content modification information:
- This page was last modified on 4 October 2008, at 05:20.
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