This MedLibrary.org supplementary page on Xylamidine is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
 |
|
|
Xylamidine
|
|
| Systematic (IUPAC) name | |
| N'-[2-(3-methoxyphenoxy)propyl]-2-(3-methylphenyl)ethanimidamide | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C19H24N2O2 |
| Mol. mass | 312.406 g/mol |
| SMILES | & |
| Synonyms | Xylamidine |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Xylamidine is a drug which acts as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A receptor. It does not cross the blood brain barrier which makes it useful for blocking peripheral serotonergic responses like cardiovascular12 and gastrointestinal effects,3 without producing the central effects of 5HT2A blockade such as sedation, or interfering with the central actions of 5HT2A agonists.4
 |
This pharmacology-related article is a stub. You can help Wikipedia by expanding it. |
References
- ^ Fuller RW, Kurz KD, Mason NR, Cohen ML. Antagonism of a peripheral vascular but not an apparently central serotonergic response by xylamidine and BW 501C67. European Journal of Pharmacology. 1986 Jun 5;125(1):71-7. PMID 3732393
- ^ Dedeoğlu A, Fisher LA. Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms. Journal of Pharmacology and Experimental Therapeutics. 1991 Dec;259(3):1027-34. PMID 1762059
- ^ Baker BJ, Duggan JP, Barber DJ, Booth DA. Effects of dl-fenfluramine and xylamidine on gastric emptying of maintenance diet in freely feeding rats. European Journal of Pharmacology. 1988 May 20;150(1-2):137-42. PMID 3402534
- ^ Dave KD, Quinn JL, Harvey JA, Aloyo VJ. Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit. Pharmacology, Biochemistry and Behaviour. 2004 Mar;77(3):623-9. PMID 15006475
|
||||||||||||||||||||||||||||||
Wikipedia content modification information:
- This page was last modified on 27 July 2008, at 01:48.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Xylamidine".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.