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In enzymology, a xylose isomerase (EC 5.3.1.5) is an enzyme that catalyzes the chemical reaction

D-xylose D-xylulose

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is D-xylose aldose-ketose-isomerase. Other names in common use include D-xylose isomerase, D-xylose ketoisomerase, and D-xylose ketol-isomerase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism. The enzyme is used industrially to convert glucose to fructose in the manufacture of high-fructose corn syrup. It is sometimes referred to as "glucose isomerase".

Structural studies

As of late 2007, 73 structures have been solved for this class of enzymes, with PDB accession codes 1A0C, 1A0D, 1A0E, 1BHW, 1BXB, 1BXC, 1CLK, 1DID, 1DIE, 1DXI, 1GW9, 1MNZ, 1MUW, 1O1H, 1OAD, 1QT1, 1S5M, 1S5N, 1XIA, 1XIB, 1XIC, 1XID, 1XIE, 1XIF, 1XIG, 1XIH, 1XII, 1XIJ, 1XIM, 1XIN, 1XIS, 1XLA, 1XLB, 1XLC, 1XLD, 1XLE, 1XLF, 1XLG, 1XLH, 1XLI, 1XLJ, 1XLK, 1XLL, 1XLM, 1XYA, 1XYB, 1XYC, 1XYL, 1XYM, 2G4J, 2GLK, 2GUB, 2GVE, 2GYI, 2XIM, 2XIN, 2XIS, 3XIM, 3XIN, 3XIS, 4XIA, 4XIM, 4XIS, 5XIA, 5XIM, 5XIN, 6XIA, 6XIM, 7XIM, 8XIA, 8XIM, 9XIA, and 9XIM.

References

• IUBMB entry for 5.3.1.5
• BRENDA references for 5.3.1.5 (Recommended.)
• PubMed references for 5.3.1.5
• PubMed Central references for 5.3.1.5
• Google Scholar references for 5.3.1.5
• HOCHSTER RM, WATSON RW (1954). "Enzymatic isomerization of D-xylose to D-xylulose". Arch. Biochem. Biophys. 48: 120–9. doi:10.1016/0003-9861(54)90313-6. PMID 13125579. 
• Slein MW (1955). "Xylose isomerase from Pasteurella pestis, strain A-1122". J. Am. Chem. Soc. 77: 1663–1667. doi:10.1021/ja01611a074. 
• Yamanaka K (1968). "Purification, crystallization and properties of the D-xylose isomerase from Lactobacillus brevis". Biochim. Biophys. Acta. 151: 670–80. PMID 5646045. 

External links

The CAS registry number for this enzyme class is 9023-82-9.

• IUBMB entry for 5.3.1.5

• KEGG entry for 5.3.1.5

• BRENDA entry for 5.3.1.5

• NiceZyme view of 5.3.1.5

• EC2PDB: PDB structures for 5.3.1.5

• PRIAM entry for 5.3.1.5

• PUMA2 entry for 5.3.1.5

• IntEnz: Integrated Enzyme entry for 5.3.1.5

• MetaCyc entry for 5.3.1.5

• Atomic-resolution structures of enzymes belonging to this class
• Xylose isomerase family signatures in PROSITE

Gene Ontology (GO) codes

• EGO entry for GO code 0009045: xylose isomerase

• AMIGO entry for GO code 0009045: xylose isomerase

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• This page was last modified on 18 November 2008, at 13:19.

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