YME1L1

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YME1-like 1 (S. cerevisiae)
Identifiers
Symbols YME1L1; FTSH; MEG4; PAMP; YME1L
External IDs OMIM: 607472 MGI: 1351651 HomoloGene: 31996
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10730 27377
Ensembl ENSG00000136758 ENSMUSG00000026775
Uniprot Q96TA2 Q8C597
Refseq NM_014263 (mRNA)
NP_055078 (protein)		 NM_013771 (mRNA)
NP_038799 (protein)
Location Chr 10: 27.44 - 27.48 Mb Chr 2: 22.98 - 23.02 Mb
Pubmed search [1] [2]

YME1-like 1 (S. cerevisiae), also known as YME1L1, is a human gene.1

The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Two transcript variants encoding different isoforms have been found for this gene.1

References

  1. ^ a b "Entrez Gene: YME1L1 YME1-like 1 (S. cerevisiae)".

Further reading

  • Coppola M, Pizzigoni A, Banfi S, et al. (2000). "Identification and characterization of YME1L1, a novel paraplegin-related gene.". Genomics 66 (1): 48–54. doi:10.1006/geno.2000.6136. PMID 10843804. 
  • Shah ZH, Hakkaart GA, Arku B, et al. (2000). "The human homologue of the yeast mitochondrial AAA metalloprotease Yme1p complements a yeast yme1 disruptant.". FEBS Lett. 478 (3): 267–70. PMID 10930580. 
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152. 
  • Pellegrini L, Passer BJ, Canelles M, et al.. PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2.. 3. pp. 181–190. PMID 12214059. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
 This article on a gene on chromosome 10 is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

  • This page was last modified on 9 July 2008, at 04:55.

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