ZNF9

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CCHC-type zinc finger, nucleic acid binding protein
Identifiers
Symbols CNBP; CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9
External IDs OMIM: 116955 MGI: 88431 HomoloGene: 2567
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7555 12785
Ensembl ENSG00000169714 ENSMUSG00000030057
Uniprot P62633 Q3U5V2
Refseq NM_003418 (mRNA)
NP_003409 (protein)		 NM_013493 (mRNA)
NP_038521 (protein)
Location Chr 3: 130.37 - 130.39 Mb Chr 6: 87.81 - 87.82 Mb
Pubmed search [1] [2]

CCHC-type zinc finger, nucleic acid binding protein, also known as CNBP, is a human gene.1

The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in myotonic dystrophy type 2 (MIM 602668).[supplied by OMIM]1

References

  1. ^ a b "Entrez Gene: CNBP CCHC-type zinc finger, nucleic acid binding protein".

Further reading

  • Lusis AJ, Rajavashisth TB, Klisak I, et al. (1991). "Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24.". Genomics 8 (2): 411–4. PMID 2249857. 
  • Rajavashisth TB, Taylor AK, Andalibi A, et al. (1989). "Identification of a zinc finger protein that binds to the sterol regulatory element.". Science 245 (4918): 640–3. PMID 2562787. 
  • Flink IL, Morkin E (1995). "Organization of the gene encoding cellular nucleic acid-binding protein.". Gene 163 (2): 279–82. PMID 7590281. 
  • Warden CH, Krisans SK, Purcell-Huynh D, et al. (1995). "Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing.". Genomics 24 (1): 14–9. doi:10.1006/geno.1994.1576. PMID 7896269. 
  • Ricker K, Grimm T, Koch MC, et al. (1999). "Linkage of proximal myotonic myopathy to chromosome 3q.". Neurology 52 (1): 170–1. PMID 9921867. 
  • Liquori CL, Ricker K, Moseley ML, et al. (2001). "Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9.". Science 293 (5531): 864–7. doi:10.1126/science.1062125. PMID 11486088. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • McGrath CF, Buckman JS, Gagliardi TD, et al. (2003). "Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein.". J. Virol. 77 (15): 8524–31. PMID 12857921. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Vallo L, Bonifazi E, Borgiani P, et al. (2005). "Characterization of a single nucleotide polymorphism in the ZNF9 gene and analysis of association with myotonic dystrophy type II (DM2) in the Italian population.". Mol. Cell. Probes 19 (1): 71–4. doi:10.1016/j.mcp.2004.09.003. PMID 15652222. 
  • Botta A, Caldarola S, Vallo L, et al. (2006). "Effect of the [CCTG]n repeat expansion on ZNF9 expression in myotonic dystrophy type II (DM2).". Biochim. Biophys. Acta 1762 (3): 329–34. doi:10.1016/j.bbadis.2005.11.004. PMID 16376058. 
  • Margolis JM, Schoser BG, Moseley ML, et al. (2006). "DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression.". Hum. Mol. Genet. 15 (11): 1808–15. doi:10.1093/hmg/ddl103. PMID 16624843. 
  • Toth C, Dunham C, Suchowersky O, et al. (2007). "Unusual clinical, laboratory, and muscle histopathological findings in a family with myotonic dystrophy type 2.". Muscle Nerve 35 (2): 259–64. doi:10.1002/mus.20685. PMID 17068784. 
  • Gerbasi VR, Link AJ (2007). "The myotonic dystrophy type 2 protein ZNF9 is part of an ITAF complex that promotes cap-independent translation.". Mol. Cell Proteomics 6 (6): 1049–58. doi:10.1074/mcp.M600384-MCP200. PMID 17327219. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 

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