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Zieve's syndrome is an acute metabolic condition that can occur during withdrawal from prolonged alcohol abuse. It is defined by hemolytic anemia, hyperlipoproteinaemia (excessive blood lipoprotein), jaundice, and abdominal pain.¹ The underlying cause is liver delipidization. This is distinct from alcoholic hepatitis, which however may be subsequent or copresent.

History

Zieve's syndrome was initially described in 1958.² Dr Zieve described patients with a combination of alcoholic liver disease, hemolytic anemia and hypertriglyceridemia.

References

1. ^ Mehta, AB; N McIntyre (2004). Oxford Textbook of Clinical Hepatology. Oxford University Press, 1786–1787. ISBN 0-19-262515-2. 
2. ^ Zieve, L (March 1958). "Jaundice, hyperlipemia and hemolytic anemia: a heretofore unrecognized syndrome associated with alcoholic fatty liver and cirrhosis". Annals of Internal Medicine 48: 471–476. PMID 13521581. 

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