Zofenopril

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Zofenopril
Systematic (IUPAC) name
(2S,4S)-1-[(2S)-3-(Benzoylsulfanyl)-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid
Identifiers
CAS number 81872-10-8
ATC code C09AA15
PubChem 92400
Chemical data
Formula C22H23NO4S2 
Mol. mass 429.552 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes Oral

Zofenopril (also known as Zofenoprilum [Latin]) is an angiotensin converting enzyme (ACE) inhibitor with cardioprotective properties indicated for the treatment of hypertension.[1]

In small studies, zofenopril appeared significantly more effective than the older antihypertensives atenolol and enalapril, and was associated with less adverse effects.[2][3]

References

  1. ^ Ambrosioni E (2007). "Defining the role of zofenopril in the management of hypertension and ischemic heart disorders". Am J Cardiovasc Drugs 7 (1): 17–24. PMID 17355163. 
  2. ^ Nilsson P (October 2007). "Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension". Blood Press Suppl 2: 25–30. PMID 18046976. 
  3. ^ Mallion JM (October 2007). "An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension". Blood Press Suppl 2: 13–8. PMID 18046974. 
Structure of captopril, the first clinically successful ACE inhibitor  This antihypertensive-related article is a stub. You can help Wikipedia by expanding it.
Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Agents acting on the renin-angiotensin system (C09)
ACE inhibitors
Angiotensin II receptor antagonists (AIIRA)
Renin inhibitors

Wikipedia content modification information:

  • This page was last modified on 29 May 2008, at 15:14.

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