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Zolazepam
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| Systematic (IUPAC) name | |
| 6-(2-fluorophenyl)-2,8,10-trimethyl -2,5,9,10-tetrazabicyclo[5.3.0]deca-5,8,11-trien-3-one | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C15H15FN4O |
| Mol. mass | 286.304 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Zolazepam (Flupyrazapon) is a pyrazolodiazepinone derivative structurally related to the benzodiazepine drugs, which is used as an anaesthetic for a wide range of animals in veterinary medicine. Zolazepam is usually administered in combination with other drugs such as the NMDA antagonist tiletamine or the alpha-2 adrenergic receptor agonist xylazine, depending on what purpose it is being used for.
Zolazepam, in combination with tiletamine, has been used in the tranquilization of wild animals, such as gorillas and polar bears, and has been found to be in terms of reduced side-effects superior to ketamine.12
References
- ^ Sleeman JM; Cameron K, Mudakikwa AB, Nizeyi JB, Anderson S, Cooper JE, Richardson HM, Macfie EJ, Hastings B, Foster JW. (March 2000). "Field anesthesia of free-living mountain gorillas (Gorilla gorilla beringei) from the Virunga Volcano region, Central Africa.". Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 31 (1): 9-14. PMID 10884117.
- ^ Cattet MR; Caulkett NA, Polischuk SC, Ramsay MA. (September 1999). "Anesthesia of polar bears (Ursus maritimus) with zolazepam-tiletamine, medetomidine-ketamine, and medetomidine-zolazepam-tiletamine.". Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 30 (3): 354-60. PMID 10572857.
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- This page was last modified on 1 November 2008, at 10:01.
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