Zotepine

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Zotepine
Systematic (IUPAC) name
2-((8-Chlorodibenzo(b,f)thiepin-
10-yl)oxy)-N,N-dimethylethylamine
Identifiers
CAS number 26615-21-4
ATC code N05AX11
PubChem 5736
DrugBank none
Chemical data
Formula C18H18ClNOS 
Mol. mass 331.86
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status

Unscheduled, Rx Only. (not approved in the U.S.)
Routes Oral

Zotepine (Nipolept, Losizopilon, Lodopin, Setous) is an atypical antipsychotic indicated for acute and chronic schizophrenia. It has been used in Germany since 1990 and Japan since 1982.

The most common dosage used is 150 mg daily. It is suggested that zotepine therapy starts at 75 mg to 150 mg divided into three daily doses. Some people may need to have their dosage increased to 300 mg.

Pharmacology

The antipsychotic effect of zotepine is thought to be mediated through antagonist activity at dopamine and serotonin receptors. Zotepine has a high affinity for the dopamine D1 and D2 recepetors. It also affects the 5HT2a, 5HT2c, 5HT6, and 5HT7 receptors. In addition, it inhibits the reuptake of noradrenaline. It is thought that this is why zotepine has a high efficacy for the negative symptoms of schizophrenia.

Side effects

The most common side effect of Zotepine is weight gain. This weight gain side effect compares badly to the older typical antipsychotics. Somnolence is the second most common side effect. Constipation, asthenia, dry mouth, and akathisia are also reported.

The likelihood of side effects are as follows:

Weight gain: Medium to high Hyperprolactinemia: high Sexual problems: high Sedation: high EPSE's (Assumes that normal doses are used but may vary with the dose given):Low Hypotension: Medium Hyperglycaemia: Low

References

v • d • e
Psycholeptics: antipsychotics - primarily dopamine antagonists (N05A)
Typical
Other
Atypical
Other D2 selective
D4 selective


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Wikipedia content modification information:

  • This page was last modified on 23 November 2008, at 20:59.

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