Our library of drug research abstracts drawn from the medical literature is updated on a regular schedule, and you can be assured that new desogen research articles will be listed here shortly after becoming available to us.
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Medical research on desogen
Duramed Pharmaceuticals targets women's health.
Contracept Technol Update. 2000 Feb; 21(2): 19-21
Contraception. 1998 May; 57(5 Suppl): 1S-27S
Lammers P, Blumenthal PD, Huggins GR
Contraception. 1997 Apr; 55(4): 219-24
Crook D
We assessed endocrine function and plasma lipid and lipoprotein concentrations in 112 women given a monophasic oral contraceptive containing 30 micrograms ethinyl estradiol and 150 micrograms desogestrel. These women were participating in a larger trial of cycle control and safety. Plasma concentrations of gonadotrophins, estradiol, and progesterone fell over the 18 months of this study, consistent with suppression of the hypothalamic-pituitary-ovarian (HPO) axis. There was no consistent effect on plasma prolactin concentrations. Concentrations of total triiodothyronine, thyroxine, and cortisol increased, tracking increases in their binding proteins. Within 6 months, plasma total cholesterol concentrations had increased by 12% (p < 0.001) with no effect on those of low density lipoproteins. Concentrations of triglycerides and high-density lipoprotein cholesterol increased by 79% and 14%, respectively (both p < 0.001). Monophasic ethinyl estradiol/desogestrel effectively suppressed the HPO axis. Other endocrine changes were typical of oral contraceptives containing ethinyl estradiol. The increase in triglyceride concentrations is not considered to increase cardiovascular risk, whereas the increase in high-density lipoproteins may be protective.
New progestin oral contraceptives and the female condom.
Pediatr Ann. 1995 Apr; 24(4): 211-6
Gold MA
Parasitol Res. 1990; 76(4): 306-10
Schaub GA
To investigate the pathogenic effects of the trypanosome Blastocrithidia triatomae on Triatoma infestans, a method for direct infection by in vitro feeding was developed. After isolation of B. triatomae cysts from infected dead bugs, a suspension of cysts was disinfected with Desogen and Chloramin T, then mixed with sterile blood, spread on a sterile, parallel-grooved glass plate or a hammered aluminium plate and covered with a thin, sterile silicone membrane. The blood and plate were warmed to 36 degrees-38 degrees C by a heating plate. For investigation of the pathological effects, first instars of T. infestans were allowed to feed through the membrane on a mixture containing 10(6) cyst stages/cm3 blood. Development of about 30% of the third and fourth instar larvae was retarded as compared with that in uninfected control groups, and mortality rates increased in fourth and/or fifth instar larvae. Whereas total mortality rates of about 5% occurred in control groups, about 85% of the larvae died in the infected groups. These effects are very similar to those obtained in previous studies with coprophagic infections.
Ann Ig. 1989 Sep-Oct; 1(5): 1255-67
De Fusco R, Biscardi D, Mazzacca FR
Containers made with PET (Polyethylene-terephthalate) are currently more and more employed in packing industry, particularly for the storage of mineral waters. The increasing utilization of such containers is due to the intrinsic properties of this polymer, which was shown particularly suitable for making bottles devoted to the storage of gassed drinks. The resistance of the PET to high pressure, hits by falls and top-to-down loads indeed makes PET bottles unbreakable; their gas-tightness warrants a good gas maintenance during the storage period; the high transparency of the PET allows a good vision of the contents; the light weight of the bottles and the low temperatures required for their production allow a remarkable saving of energy; lastly PET bottles can easily be recycled. Previous microbiological investigations carried out on several mineral waters bottled in glass bottles and non-PET plastic (i.e. PVC) bottles, had shown higher microbial counts in the water samples stored in plastic bottles. In the present work we have studied the growth rates of the bacterial flora in a sample of non gassed medio-mineral water stored in PET bottles, with respect to a control of the same kind of water, stored in glass bottles. Before using, both PET and glass bottles were washed with 5% Desogen, and sterilized by 100 vol. hydrogen peroxide. After the appropriate sterility checks, the bottles were filled directly from the spring with a non gassed medio-mineral water, and then subdivided into four groups, each consisting of the same number of bottles. A the time of bottling, a bacterial count on such water samples at 20 degrees C and 37 degrees C was performed, in order to establish the "zero" value. One of the two groups of PET bottles, and one of the two groups of glass bottles were stored in the darkness, while the other two groups were stored in the light. Afterwards, one bottle from each group was drawn once a week over one year, in order to measure the bacterial concentration in the water. 20 degrees C and 37 degrees C bacterial counts were done after plating in standard agar. The findings of our study show that the bacterial count in both PET- and glass-stored water increases first, but decreases afterwards, though in a non-uniform rate. Further, light exposure weakly don't affects significantly the bacterial growth, even though, in the average, the bacterial count is lower in the bottles exposed to the light.(ABSTRACT TRUNCATED AT 400 WORDS)
Prax Klin Pneumol. 1988 May; 42(5): 172-4
Rüsch-Gerdes S, Schröder KH, Pfohl M
Quad Sclavo Diagn. 1981 Sep; 17(3): 277-82
Tortoli E
The percentages of positive cultures of mycobacteria obtained from sputum, bronchial-aspirate and urine treated with 0.2% Bactofen and with 0.5% Desogen were compared. Respiratory materials gave significantly higher values of these percentages when treated with Bactofen. Urine showed opposite results but these were not statistically significant. Isolates of MOTT too were more frequent in specimens decontaminated with Bactofen. Contamination rate showed no modifications.
Quad Sclavo Diagn. 1980 Jun; 16(2): 196-205
Carpi Torelli P, Tortoli E
We tried to see whether it was possible to use Bactofen to decontaminate sputum for culture of Mycobacterium tuberculosis. Bactofen showed very little bactericidal action on tubercle bacilli, lower than Desogen, and selectively destroyed many contaminants, more actively than benzalkonium chloride. Digested sputum decontaminated with 0.2% Bactofen and then applied to culture media without centrifugation gave good results in growth of colonies.
Quad Sclavo Diagn. 1979 Jun; 15 Suppl 1: 770-6
Levré E, Armani G, Caroli G
Several antiseptic and disinfectant compounds have been investigated for their minimal inhibitory concentration (MIC) against antibiotic multiresistant strains of S. wien and S. bredeney as well as S. typhi and S. typhimurium strains characterized by wide spectrum of antibiotic sensitivity. The MICs of AgNO3, merthiolate, NaN3, phenol, Zephiran and Desogen were not substantially different for the former and the latter strains; on the contrary, the HgCl2 minimal inhibitory concentration was significantly higher against S. wien and S. bredeney than against the other strains. The mercury resistance appeared plasmid controlled and transferable to E. coli K-12, always associated with antibiotic resistance. The findings, which confirm the results of other AA., seem unrestrictive of the use of HgCl2, because its not probable selective role in the hospital environment.