Our library of drug research abstracts drawn from the medical literature is updated on a regular schedule, and you can be assured that new lo-ovral research articles will be listed here shortly after becoming available to us.
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Medical research on lo-ovral
10 common questions on emergency contraception.
Contracept Technol Update. 1998 Jan; 19(1): 6, 11-2
Hatcher RA
Experience and acceptability of emergency hormonal contraception.
Prim Care Update Ob Gyns. 1998 Jul 1; 5(4): 172
Hakim-Elahi E, Breitbart V
Objective: The study was designed to evaluate the experience and acceptability of emergency hormonal contraception service for inner-city women in Planned Parenthood clinics.Methods: In 1995, emergency hormonal contraception was introduced as a new service in three clinics of New York City's Planned Parenthood that served low-income women. Shortly after inception of this service, the agency undertook a survey to investigate patient experience and acceptability of the service. The survey addressed side effects and patients attitudes about emergency hormonal contraception. It also addressed suggestions for improving the service.The indication for the use of this method was unprotected intercourse within the previous 72 hours of first dosage of certain birth control pills. We used Lo/Ovral (norgestrel 0.3 mg + ethinyl estradiol 30 µg) 4 tablets given stat and second dose 12 hours later.Results: There were 118 patients who responded to the survey. The average patient age was 25 years. Approximately half of the women were white and half were other. The majority were nulliparous, and 42% had one or more abortions in the past. Side effects such as nausea, vomiting, and fatigue and their prevalence were noted. Two women reported method failure. Both patients elected abortion. The vast majority (92%) stated that they would use the method again. Patients also made several recommendations for enhancing the service.Conclusion: As a result of this survey, Planned Parenthood of New York City completely revised its emergency hormonal contraception protocols in order to increase patient satisfaction while maintaining high medical standards to ensure lower method failure and drug side effects in more than 1,000 patients so far.
Emergency contraception as a backup method.
Network. 1997; 17(2): 12-3
Barnett B
FDA finds emergency postcoital contraception safe and effective.
Reprod Freedom News. 1996 Jul 12; 5(12): 7
OCs provide emergency contraception option.
Network. 1996; 16(4): 14-7
Blaney CL
Reprod Freedom News. 1994 Dec 2; 3(21): 4-5
J Clin Endocrinol Metab. 1994 Nov; 79(5): 1277-83
Watanabe RM, Azen CG, Roy S, Perlman JA, Bergman RN
We performed oral glucose tolerance tests and frequently sampled iv glucose tolerance tests in a cross-sectional sample of women taking monophasic norgestrel containing oral contraceptives (OC). The goal of the study was to quantify the individual factors that determine glucose tolerance to assess responsibility for the reduced glucose tolerance associated with the use of OCs. Subjects were selected using stringent criteria to exclude confounding effects of ethnicity, adiposity, or conditions that may predispose subjects to metabolic disorders. Users of the low dose OC (Lo/Ovral and Nordette) and high dose OC (Ovral) were compared to controls, who were required to never have used OCs or to have discontinued OC use for at least 24 months. Oral glucose tolerance tests results confirmed the development of impaired glucose tolerance in both pill groups. Frequently sampled iv glucose tolerance test data were analyzed using the minimal model method to estimate parameters of insulin sensitivity, glucose effectiveness (SG), and beta-cell function. Lo/Ovral users had lower insulin sensitivity and SG compared to controls and inappropriately low beta-cell function in relation to the insulin resistance. Ovral users had metabolic parameters that were not different from controls. Based upon comparisons between normal and impaired glucose tolerant subjects combined with stepwise regression analysis, we conclude that Lo/Ovral use results in insulin and glucose resistance, which is not compensated by increased beta-cell function. The reduced glucose tolerance is due primarily to the defect in SG, and these OC users may place themselves at higher risk for the development of diabetes or cardiovascular disease. The reduced tolerance in Ovral users cannot be explained by the parameters measured in this study. We speculate that these latter subjects represent a special self-selected population in which tolerance is regulated by other factors. Ovral appears to be well tolerated by these women.
Emergency contraceptive pills (ECP) protocol.
Contracept Technol Update. 1994 May; 15(5): 63-4
Postcoital pills could cut unplanned pregnancies by half.
Contracept Technol Update. 1993 Mar; 14(3): 33-6, 39
Emergency contraceptive pills: a simple proposal to reduce unintended pregnancies.
Fam Plann Perspect. 1992 Nov-Dec; 24(6): 269-73
Trussell J, Stewart F, Guest F, Hatcher RA