Acyclovir (Page 4 of 4)
Intermittent Therapy: 200 mg every 4 hours, 5 times daily for 5 days. Therapy should be initiated at the earliest sign or symptom (prodrome) of recurrence.
Treatment of Chickenpox
Children (2 years of age and older): 20 mg/kg per dose orally 4 times daily (80 mg/kg/day) for 5 days. Children over 40 kg should receive the adult dose for chickenpox.
Adults and Children over 40 kg: 800 mg 4 times daily for 5 days.
Intravenous acyclovir is indicated for the treatment of varicella-zoster infections in immunocompromised patients.
When therapy is indicated, it should be initiated at the earliest sign or symptom of chickenpox. There is no information about the efficacy of therapy initiated more than 24 hours after onset of signs and symptoms.
Patients With Acute or Chronic Renal Impairment
In patients with renal impairment, the dose of acyclovir tablets should be modified as shown in Table 3:
| Normal Dosage Regimen | Creatinine Clearance mL/min/1.73 m 2) | Adjusted Dosage Regimen | |
| Dose (mg) | Dosing Interval | ||
| 200 mg every 4 hours | >10 0-10 | 200 200 | every 4 hours, 5x daily every 12 hours |
| 400 mg every 12 hours | >10 0-10 | 400 200 | every 12 hours every 12 hours |
| 800 mg every 4 hours | >25 10-25 0-10 | 800 800 800 | every 4 hours, 5x daily every 8 hours every 12 hours |
Hemodialysis
For patients who require hemodialysis, the mean plasma half-life of acyclovir during hemodialysis is approximately 5 hours. This results in a 60% decrease in plasma concentrations following a 6-hour dialysis period. Therefore, the patient’s dosing schedule should be adjusted so that an additional dose is administered after each dialysis.
Peritoneal Dialysis
No supplemental dose appears to be necessary after adjustment of the dosing interval.
Bioequivalence of Dosage Forms
Acyclovir Suspension was shown to be bioequivalent to acyclovir Capsules (n = 20) and 1 acyclovir 800-mg tablet was shown to be bioequivalent to 4 acyclovir 200-mg capsules (n = 24).
HOW SUPPLIED
Acyclovir Tablets, 800 mg (white to off-white, unscored, oval and engraved with “
”)
Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]
Protect from moisture. Keep this and all medication out of the reach of children.
Manufactured and distributed by:
Carlsbad Technology, Inc.
5923 Balfour Ct.
Carlsbad, CA 92008 USA
OR
Manufactured by:
Yung Shin Pharm. Ind. (KS) Co., Ltd.
No.191 Jin Yang West Road, Lujia, Kunshan, Jiangsu, China
Packaged and distributed by:
Carlsbad Technology, Inc.
5923 Balfour Ct.
Carlsbad, CA 92008 USA
CTI-10 REV. C
REVISED: APRIL 2013
PRINCIPAL DISPLAY PANEL
NDC 53217-0313
Acyclovir
Tablets USP
800 mg
Rx Only
Carlsbad Technology, Inc.
Repackaged by:
Aidarex Pharmaceuticals, LLC
Corona, CA 92880
53217-0313_Acyclovir_800MG
| ACYCLOVIR acyclovir tablet | ||||||||||||||||||
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| Labeler — Aidarex Pharmaceuticals LLC (801503249) |
Revised: 05/2018 Aidarex Pharmaceuticals LLC
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