Amantadine Hydrochloride (Page 5 of 5)
Dosage for Concomitant Therapy
Some patients who do not respond to anticholinergic antiparkinson drugs may respond to amantadine hydrochloride capsules. When amantadine hydrochloride capsules or anticholinergic antiparkinson drugs are each used with marginal benefit, concomitant use may produce additional benefit.
When amantadine and levodopa are initiated concurrently, the patient can exhibit rapid therapeutic benefits. Amantadine hydrochloride capsules should be held constant at 100 mg daily or twice daily while the daily dose of levodopa is gradually increased to optimal benefit.
When amantadine is added to optimal well-tolerated doses of levodopa, additional benefit may result, including smoothing out the fluctuations in improvement which sometimes occur in patients on levodopa alone. Patients who require a reduction in their usual dose of levodopa because of development of side effects may possibly regain lost benefit with the addition of amantadine hydrochloride capsules.
Dosage for Drug Induced Extrapyramidal Reactions
Adult
The usual dose of amantadine hydrochloride capsules is 100 mg twice a day. Occasionally, patients whose responses are not optimal with amantadine hydrochloride capsules at 200 mg daily may benefit from an increase up to 300 mg daily in divided doses.
Dosage for Impaired Renal Function
Depending upon creatinine clearance, the following dosage adjustments are recommended:
CREATININE CLEARANCE (mL/min/1.73m2) | AMANTADINE HYDROCHLORIDE CAPSULES DOSAGE |
30 to 50 | 200 mg 1st day and 100 mg each day thereafter |
15 to 29 | 200 mg 1st day followed by 100 mg on alternate days |
<15 | 200 mg every 7 days |
The recommended dosage for patients on hemodialysis is 200 mg every 7 days.
HOW SUPPLIED
Amantadine hydrochloride capsules, USP for oral administration are available as:
100 mg: Red capsules imprinted GG 634 and supplied as:
NDC 33261-0773-10 bottles of 10
NDC 33261-0773-30 bottles of 30
NDC 33261-0773-60 bottles of 60
NDC 33261-0773-90 bottles of 90
Store at 20°-25°C (68°-77°F) (see USP Controlled Room Temperature).
Dispense in a tight, light-resistant container as defined in the USP.
REFERENCES
- 1.W.W. Wilson and A.H. Rajput, Amantadine-Dyazide Interaction, Can Med Assoc J. 129:974-975, 1983.
- 2.D.F. Casey, N. Engl. J. Med. 298:516, 1978.
- 3.C.D. Berkowitz, J. Pediatr. 95:144, 1979.
06-2009M
7262
Sandoz Inc.
Princeton, NJ 08540
Repackaged By :
Aidarex Pharmaceuticals LLC,
Corona, CA 92880
100 mg Label
NDC 33261-0773-60
Amantadine
Hydrochloride
Capsules, USP
100 mg
Rx only
60 Capsules
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Labeler — Aidarex Pharmaceuticals LLC (801503249) |
Revised: 11/2013 Aidarex Pharmaceuticals LLC
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