Amoxicillin (Page 4 of 6)
Neonates and infants aged ≤ 12 weeks (≤ 3 months):
Due to incompletely developed renal function affecting elimination of amoxicillin in this age group, the recommended upper dose of amoxicillin is 30 mg/kg/day divided q12h.
| * Dosing for infections caused by less susceptible organisms should follow the recommendations for severe infections. | |||
| † The children’s dosage is intended for individuals whose weight is less than 40 kg. Children weighing 40 kg or more should be dosed according to the adult recommendations. | |||
| Infection | Severity* | Usual | Usual Dose |
| Adult Dose | for Children | ||
| >3 months † | |||
| Ear/nose/throat | Mild/Moderate | 500 mg | 25 mg/kg/day |
| every 12 hours | in divided doses | ||
| or | every 12 hours | ||
| 250 mg | or | ||
| every 8 hours | 20 mg/kg/day | ||
| in divided doses | |||
| every 8 hours | |||
| Severe | 875 mg | 45 mg/kg/day | |
| every 12 hours | in divided doses | ||
| or | every 12 hours | ||
| 500 mg | or | ||
| every 8 hours | 40 mg/kg/day | ||
| in divided doses | |||
| every 8 hours | |||
| Lower respiratory | Mild/Moderate | 875 mg | 45 mg/kg/day |
| Tract | or Severe | every 12 hours | in divided doses |
| or | every 12 hours | ||
| 500 mg every | or | ||
| 8 hours | 40 mg/kg/day | ||
| in divided doses | |||
| every 8 hours | |||
| Skin/Skin | Mild/Moderate | 500 mg | 25 mg/kg/day |
| Structure | every 12 hours | in divided doses | |
| or | every 12 hours | ||
| 250 mg every | or | ||
| 8 hours | 20 mg/kg/day | ||
| in divided doses | |||
| every 8 hours | |||
| Severe | 875 mg | 45 mg/kg/day | |
| every 12 hours | in divided doses | ||
| or | every 12 hours | ||
| 500 mg every | or | ||
| 8 hours | 40 mg/kg/day | ||
| in divided doses | |||
| every 8 hours | |||
| Genitourinary | Mild/Moderate | 500 mg | 25 mg/kg/day |
| Tract | every 12 hours | in divided doses | |
| or | every 12 hours | ||
| 250 mg every | or | ||
| 8 hours | 20 mg/kg/day | ||
| in divided doses | |||
| every 8 hours | |||
| Severe | 875 mg | 45 mg/kg/day | |
| every 12 hours | in divided doses | ||
| or | every 12 hours | ||
| 500 mg | or | ||
| every 8 hours | 40 mg/kg/day | ||
| in divided doses | |||
| every 8 hours | |||
| Gonorrhea | 3 grams | Prepubertal children: | |
| Acute, | as | 50 mg/kg amoxicillin combined with | |
| uncomplicated | single oral dose | 25 mg/kg probenecid as a single dose. | |
| ano-genital and | NOTE: SINCE PROBENECID IS CONTRA- | ||
| urethral infections in males and females | INDICATED IN CHILDREN UNDER 2 YEARS. DO NOT USE THIS REGIMEN IN THESE CASES. | ||
All patients with gonorrhea should be evaluated for syphilis. (See PRECAUTIONS — Laboratory Tests.)
Larger doses may be required for stubborn or severe infections.
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