Antizol (Page 3 of 3)

Discontinuation of Antizol Treatment

Treatment with Antizol may be discontinued when ethylene glycol or methanol concentrations are undetectable or have been reduced below 20 mg/dL, and the patient is asymptomatic with normal pH.

Dosing of Antizol

A loading dose of 15 mg/kg should be administered, followed by doses of 10 mg/kg every 12 hours for 4 doses, then 15 mg/kg every 12 hours thereafter until ethylene glycol or methanol concentrations are undetectable or have been reduced below 20 mg/dL, and the patient is asymptomatic with normal pH. All doses should be administered as a slow intravenous infusion over 30 minutes (see Administration).

Dosage with Renal Dialysis

Antizol® (fomepizole) Injection is dialyzable and the frequency of dosing should be increased to every 4 hours during hemodialysis.

Antizol Dosing in Patients Requiring Hemodialysis
DOSE AT THE BEGINNING OF HEMODIALYSIS
If <6 hours since last Antizol dose If ≥6 hours since last Antizol dose
Do not administer dose Administer next scheduled dose

DOSING DURING HEMODIALYSIS

Dose every 4 hours

DOSING AT THE TIME HEMODIALYSIS IS COMPLETED
Time between last dose and the end of hemodialysis
<1 hour Do not administer dose at the end of hemodialysis
1–3 hours Administer 1/2 of next scheduled dose
>3 hours Administer next scheduled dose

MAINTENANCE DOSING OFF HEMODIALYSIS

Give next scheduled dose 12 hours from last dose administered

Administration

Antizol solidifies at temperatures less than 25° C (77° F). If the Antizol solution has become solid in the vial, the solution should be liquefied by running the vial under warm water or by holding in the hand. Solidification does not affect the efficacy, safety, or stability of Antizol. Using sterile technique, the appropriate dose of Antizol should be drawn from the vial with a syringe and injected into at least 100 mL of sterile 0.9% sodium chloride injection or dextrose 5% injection. Mix well. The entire contents of the resulting solution should be infused over 30 minutes. Antizol, like all parenteral products, should be inspected visually for particulate matter prior to administration.

Stability

Antizol diluted in 0.9% sodium chloride injection or dextrose 5% injection remains stable and sterile for at least 24 hours when stored refrigerated or at room temperature. Antizol does not contain preservatives. Therefore, maintain sterile conditions, and after dilution do not use beyond 24 hours. Solutions showing haziness, particulate matter, precipitate, discoloration, or leakage should not be used.

HOW SUPPLIED

Antizol is supplied as a sterile, preservative-free solution for intravenous use as:

Supplied in packages of four vials. Each vial contains 1.5 mL (1 g/mL) of fomepizole.

NDC 68727-200-02

Store at controlled room temperature, 20° to 25° C (68° to 77° F)

Distributed by:
Jazz Pharmaceuticals, Inc.
Palo Alto, CA 94304

For questions of a medical nature, call 1-888-867-7426.

Part No. ANT PI-8511

Revision Date: April 2006

ANTIZOL
fomepizole injection, solution
Product Information
Product Type HUMAN PRESCRIPTION DRUG Item Code (Source) NDC:68727-200
Route of Administration INTRAVENOUS DEA Schedule
Active Ingredient/Active Moiety
Ingredient Name Basis of Strength Strength
fomepizole (FOMEPIZOLE) FOMEPIZOLE 1 g in 1 mL
Packaging
# Item Code Package Description Multilevel Packaging
1 NDC:68727-200-02 4 INJECTION, SOLUTION (4 CARTON) in 1 CARTON None
2 NDC:68727-200-01 1 INJECTION, SOLUTION (1 VIAL) in 1 CARTON None
3 1.5 mL (1.5 MILLILITER) in 1 VIAL, GLASS None

Revised: 02/2007

Page 3 of 3 1 2 3

All MedLibrary.org resources are included in as near-original form as possible, meaning that the information from the original provider has been rendered here with only typographical or stylistic modifications and not with any substantive alterations of content, meaning or intent.

This site is provided for educational and informational purposes only, in accordance with our Terms of Use, and is not intended as a substitute for the advice of a medical doctor, nurse, nurse practitioner or other qualified health professional.

Privacy Policy | Copyright © 2022. All Rights Reserved.