For a comparison of toxicities when carboplatin or cisplatin was given in combination with cyclophosphamide, see CLINICAL STUDIES, Use with Cyclophosphamide for Initial Treatment of Ovarian Cancer, Comparative Toxicity.
|ADVERSE EXPERIENCES IN PATIENTS WITH OVARIAN CANCER|
|First Line Combination Therapy * Percent||Second Line Single Agent Therapy ** Percent|
|< 100,000/mm 3||66||62|
|< 50,000/mm 3||33||35|
|< 2,000 cells/mm 3||96||67|
|< 1,000 cells/mm 3||82||21|
|< 4,000 cells/mm 3||97||85|
|< 2,000 cells/mm 3||71||26|
|< 8 g/dL||14||21|
|Nausea and vomiting||93||92|
|Other GI side effects||46||21|
|Other sensory side effects||5||1|
|Serum creatinine elevations||6||10|
|Blood urea elevations||17||22|
|Alkaline phosphatase elevations||29||37|
|Other side effects|
*Use with Cyclophosphamide for Initial
Treatment of Ovarian Cancer
Data are based on the experience of 393 patients with ovarian cancer (regardless of baseline status) who received initial combination therapy with carboplatin and cyclophosphamide in two randomized controlled studies conducted by SWOG and NCIC (see CLINICAL STUDIES).
Combination with cyclophosphamide as well as duration of treatment may be responsible for the differences that can be noted in the adverse experience table.
**Single Agent Use for the Secondary Treatment of Ovarian Cancer
Data are based on the experience of 553 patients with previously treated ovarian carcinoma (regardless of baseline status) who received single-agent carboplatin.
In the narrative section that follows, the incidences of adverse events are based on data from 1,893 patients with various types of tumors who received carboplatin as single-agent therapy.
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