Cefadroxil (Page 3 of 3)
A study of children under six years of age suggested that ingestion of less than 250 mg/ kg of cephalosporins is not associated with significant outcomes. No action is required other than general support and observation. For amounts greater than 250 mg/kg, induce gastric emptying.
In five anuric patients, it was demonstrated that an average of 63% of a 1 g oral dose is extracted from the body during a 6–8 hour hemodialysis session.
DOSAGE AND ADMINISTRATION
Cefadroxil capsules are acid-stable and may be administered orally without regard to meals. Administration with food may be helpful in diminishing potential gastrointestinal complaints occasionally associated with oral cephalosporin therapy.
Urinary Tract Infections: For uncomplicated lower urinary tract infections (i.e., cystitis) the usual dosage is 1 or 2 g per day in a single (q.d.) or divided doses (b.i.d.).
For all other urinary tract infections the usual dosage is 2 g per day in divided doses (b.i.d.).
Skin and Skin Structure Infections: For skin and skin structure infections the usual dosage is 1 g per day in single (q.d.) or divided doses (b.i.d.).
Pharyngitis and Tonsillitis: Treatment of group A beta-hemolytic streptococcal pharyngitis and tonsillitis— 1 g per day in single (q.d.) or divided doses (b.i.d.) for 10 days.
For urinary tract infections, the recommended daily dosage for children is 30 mg/kg/day in divided doses every 12 hours. For pharyngitis, tonsillitis, and impetigo, the recommended daily dosage for children is 30 mg/kg/day in a single dose or in equally divided doses every 12 hours. For other skin and skin structure infections, the recommended daily dosage is 30 mg/kg/day in equally divided doses every 12 hours. In the treatment of beta-hemolytic streptococcal infections, a therapeutic dosage of cefadroxil monohydrate should be administered for at least 10 days.
In patients with renal impairment, the dosage of cefadroxil monohydrate should be adjusted according to creatinine clearance rates to prevent drug accumulation. The following schedule is suggested. In adults, the initial dose is 1000 mg of cefadroxil monohydrate and the maintenance dose (based on the creatinine clearance rate [mL/min/1.73 M ]) is 500 mg at the time intervals listed below.
|Creatinine Clearance||Dosage Interval|
|0-10 mL/min||36 hours|
|10-25 mL/min||24 hours|
|25-50 mL/min||12 hours|
Patients with creatinine clearance rates over 50 mL/min may be treated as if they were patients having normal renal function.
Cefadroxil Capsules USP, 500 mg are size ‘0’ capsules with maroon cap and white body, imprinted with “LU” (in black edible ink) on cap and with “F11” (in black edible ink) on body, containing white to off-white powder supplied as follows:
NDC 68180-180-08 Bottle of 50
NDC 68180-180-01 Bottle of 100
Store at 25°C (77°F); excursions permitted to 15° to 30° C (59° to 86° F). [See USP Controlled Room Temperature].
- National Committee for Clinical Laboratory Standards, Approved Standard,Performance Standards for Antimicrobial Disk Susceptibility Test , 4th Edition, Vol. 10 (7): M2-A4, Villanova, PA, April, 1990.
- National Committee for Clinical Laboratory Standards, Approved Standard:Methods for Dilution Antimicrobial Susceptibility Tests forBacteria that Grow Aerobically , 2nd Edition, Vol. 10 (8): M7-A2, Villanova, PA, April, 1990.
Mandideep 462 046
Lupin Pharmaceuticals, Inc.
Baltimore, Maryland 21202
May 2012 ID#225464
PACKAGE LABEL.PRINCIPAL DISPLAY PANEL
Cefadroxil Capsules USP, 500 mg
Package Label – Bottle of 100s
|CEFADROXIL cefadroxil capsule|
|Labeler — LUPIN LIMITED (675923163)|
|Registrant — LUPIN LIMITED (675923163)|
|LUPIN LIMITED||725504448||manufacture (57297-180), pack (57297-180)|
Revised: 05/2016 LUPIN LIMITED
All MedLibrary.org resources are included in as near-original form as possible, meaning that the information from the original provider has been rendered here with only typographical or stylistic modifications and not with any substantive alterations of content, meaning or intent.