Estradiol (Page 8 of 9)

Instructions for Use

Estradiol (es” tra dye’ ol) Transdermal System

Read this PATIENT INFORMATION before you start using estradiol transdermal system and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your menopausal symptoms or your treatment.

You will need the following supplies (See Figure A).

figure A
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Figure A

Step 1: Pick the days you will change your patch.

  • You will need to change your patch 2 times a week or every 3 to 4 days. Use the calendar printed inside your carton to choose the 2 days you will change your patch (See Figure B).
  • Remember to change your patch on the same 2 days you marked on your calendar. If you forget to change your patch on the correct date, apply a new patch as soon as you remember, and continue to follow your original schedule

figure B
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Figure B

Step 2: Remove the estradiol transdermal system patch from the pouch.

  • Remove the patch from its protective pouch by tearing at the notch (do not use scissors, See Figure C).
  • Do not remove your patch from the protective pouch until you are ready to apply it

Figure C
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Figure C

Step 3: Remove half of the adhesive liner (See Figure D).

Figure D
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Figure D

Step 4: Placing the patch on your skin.

  • Hold the part of the patch that still has the adhesive liner on it
  • Avoid touching the sticky half of the patch with your fingers
  • Apply the exposed sticky half of the patch to 1 of the areas of skin shown below (See Figures E and F).

Figure E
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Figure F
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Figure E Figure F

Note:

  • Avoid the waistline, since clothing and belts may cause the patch to be rubbed off
  • Do not apply the patch to your breasts
  • Only apply the patch to skin that is clean, dry, and free of any powder, oil, or lotion
  • You should not apply the patch to injured, burned, or irritated skin, or areas with skin conditions (such as birth marks, tattoos, or that is very hairy)

Step 5: Press the patch firmly onto your skin.

  • Remove the remaining half of the adhesive liner and press the entire patch into place with the palm of your hand for 10 seconds
  • Rub the edges of the patch with your fingers to make sure that it will stick to your skin (See Figure G).
Figure G
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Figure G

Note:

  • Showering will not cause your patch to fall off
  • If your patch falls off reapply it. If you cannot reapply the patch, apply a new patch to another area (See Figures E and D) and continue to follow your original placement schedule
  • If you stop using your estradiol transdermal system patch or forget to apply a new patch as scheduled, you may have spotting, or bleeding, and recurrence of symptoms

Step 6: Throwing away your used patch.

  • When it is time to change your patch, remove the old patch before you apply a new patch
  • To throw away the patch, fold the sticky side of the patch together, place it in a sturdy child-proof container, and place this container in the trash. Used patches should not be flushed in the toilet

This Patient Information and Instructions for Use have been approved by the U.S. Food and Drug Administration.

*All trademarks are the property of their respective owners.

Distributed by:
Amneal Pharmaceuticals LLC Bridgewater, NJ 08807

Rev. 11-2021-03

PRINCIPAL DISPLAY PANEL

0.025 mg/day pouch
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1
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0.0375 mg/day pouch
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2
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