No reported abuse or dependence has been associated with the administration of guanfacine.
Signs and Symptoms: Drowsiness, lethargy, bradycardia, and hypotension have been observed following overdose with guanfacine.
A 25-year-old female intentionally ingested 60 mg. She presented with severe drowsiness and bradycardia of 45 beats/minute. Gastric lavage was performed and an infusion of isoproterenol (0.8 mg in 12 hours) was administered. She recovered quickly and without sequelae.
A 28-year-old female who ingested 30-40 mg developed only lethargy, was treated with activated charcoal and a cathartic, was monitored for 24 hours, and was discharged in good health.
A 2-year-old male weighing 12 kg, who ingested up to 4 mg of guanfacine developed lethargy. Gastric lavage (followed by activated charcoal and sorbitol slurry via NG tube) removed some tablet fragments within 2 hours after ingestion, and vital signs were normal.
During 24-hour observation in ICU, systolic pressure was 58 and heart rate 70 at 16 hours post-ingestion. No intervention was required, and child was discharged fully recovered the next day.
Treatment of Overdosage: Gastric lavage and supportive therapy as appropriate. Guanfacine is not dialyzable in clinically significant amounts (2.4%).
The recommended initial dose of guanfacine hydrochloride when given alone or in combination with another antihypertensive drug is 1 mg daily given at bedtime to minimize somnolence. If after 3 to 4 weeks of therapy 1 mg does not give a satisfactory result, a dose of 2 mg may be given, although most of the effect of guanfacine is seen at 1 mg (see CLINICAL PHARMACOLOGY). Higher daily doses have been used, but adverse reactions increase significantly with doses above 3 mg/day.
The frequency of rebound hypertension is low, but it can occur. When rebound occurs, it does so after 2-4 days, which is delayed compared with clonidine hydrochloride. This is consistent with the longer half-life of guanfacine. In most cases, after abrupt withdrawal of guanfacine, blood pressure returns to pretreatment levels slowly (within 2-4 days) without ill effects.
Guanfacine tablets, USP are available in the following dosing strengths (expressed in equivalent amounts of guanfacine):
Guanfacine tablets, USP 2 mg, are peach, round tablets, debossed with WATSON 453 and are available in bottles of 100.
PACKAGING: 30 in 1 BLISTER PACK
Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].
Dispense in a tight, light-resistant container.
Repackaged and Distributed By:
Remedy Repack, Inc.
625 Kolter Dr. Suite #4 Indiana, PA 1-724-465-8762
SCORE: No score
SIZE: 8 mm
PACKAGING: 30 in 1 BLISTER PACK
- GUANFACINE HYDROCHLORIDE 2mg in 1
- ALUMINUM OXIDE
- CELLULOSE, MICROCRYSTALLINE
- STEARIC ACID
- ANHYDROUS LACTOSE
- D&C YELLOW NO. 10
- FD&C RED NO. 40
|GUANFACINE guanfacine tablet|
|Labeler — REMEDYREPACK INC. (829572556)|
Revised: 05/2021 REMEDYREPACK INC.
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