KURVELO — levonorgestrel and ethinyl estradiol
21 light orange KurveloTM tablets, each containing 0.15 mg of levonorgestrel, (d(-)-13 beta-ethyl-17-alpha-ethinyl-17-beta-hydroxygon-4-en-3-one), a totally synthetic progestogen, and 0.03 mg of ethinyl estradiol, (19-nor-17α-pregna-1,3,5 (10)-trien-20-yne-3,17-diol), and 7 pink inert tablets. The inactive ingredients present in active tablets are croscarmellose sodium, FD&C Yellow #6, lactose monohydrate, magnesium stearate, microcrystalline cellulose and povidone and in inert tablets are croscarmellose sodium, D & C Red #30, lactose monohydrate, magnesium Stearate and microcrystalline cellulose.
Combination oral contraceptives act by suppression of gonadotropins. Although the primary mechanism of this action is inhibition of ovulation, other alterations include changes in the cervical mucus (which increase the difficulty of sperm entry into the uterus) and the endometrium (which reduce the likelihood of implantation).
Oral contraceptives are highly effective. Table I lists the typical accidental pregnancy rates for users of combination oral contraceptives and other methods of contraception. The efficacy of these contraceptive methods, except sterilization and the IUD, depends upon the reliability with which they are used. Correct and consistent use of methods can result in lower failure rates.
|Method||Perfect Use||Typical Use|
|Depo-Provera® (injectable progestogen)||0.3||0.3|
|Copper T 380A||0.6||0.8|
|Condom (male) without spermicide||3||14|
|(Female) without spermicide||5||21|
|Diaphragm with spermicidal cream or jelly||6||20|
|Spermicides alone (foam, creams, jellies, and vaginal suppositories)||6||26|
|Periodic abstinence (all methods)||1 to 9*||25|
|No contraception (planned pregnancy)||85||85|
|NA — not available|
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