METFORMIN HYDROCHLORIDE (Page 5 of 8)
Drug Interactions
In Vivo Assessment of Drug Interactions
Table 5: Effect of Coadministered Drug on Plasma Metformin Systemic Exposure
Coadministered Drug | Dose of Coadministered Drug * | Dose of Metformin * | Geometric Mean Ratio (ratio with/without coadministered drug) No Effect = 1.00 | ||
AUC † | C max | ||||
No dosing adjustments required for the following: | |||||
Glyburide | 5 mg | 850 mg | metformin | 0.91‡ | 0.93‡ |
Furosemide | 40 mg | 850 mg | metformin | 1.09‡ | 1.22‡ |
Nifedipine | 10 mg | 850 mg | metformin | 1.16 | 1.21 |
Propranolol | 40 mg | 850 mg | metformin | 0.90 | 0.94 |
Ibuprofen | 400 mg | 850 mg | metformin | 1.05‡ | 1.07‡ |
Cationic drugs eliminated by renal tubular secretion may reduce metformin elimination. | |||||
Cimetidine | 400 mg | 850 mg | metformin | 1.40 | 1.61 |
Carbonic anhydrase inhibitors may cause metabolic acidosis [See Warnings and Precautions (5.1)] | |||||
Topiramate | 100 mg § | 500 mg § | metformin | 1.25§ | 1.17 |
Table 6: Effect of Metformin on Coadministered Drug Systemic Exposure
Coadministered Drug | Dose of Coadministered Drug * | Dose of Metformin * | Geometric Mean Ratio (ratio with/without metformin) No Effect = 1.00 | ||
AUC † | C max | ||||
No dosing adjustments required for the following: | |||||
Glyburide | 5 mg | 850 mg | glyburide | 0.78‡ | 0.63‡ |
Furosemide | 40 mg | 850 mg | furosemide | 0.87‡ | 0.69‡ |
Nifedipine | 10 mg | 850 mg | nifedipine | 1.10§ | 1.08 |
Propranolol | 40 mg | 850 mg | propranolol | 1.01§ | 1.02 |
Ibuprofen | 400 mg | 850 mg | ibuprofen | 0.97¶ | 1.01¶ |
Cimetidine | 400 mg | 850 mg | cimetidine | 0.95§ | 1.01 |
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