Penicillin G Potassium (Page 4 of 5)

Pediatric patients

This product should not be administered to patients requiring less than one million units per dose (see PRECAUTIONS – Pediatric Use).


Serious infections, such as pneumonia and endocarditis, due to susceptible strains of streptococci (including S. pneumoniae) and meningococcus

150,000 units/kg/day divided in equal doses every 4 to 6 hours; duration depends on infecting organism and type of infection.

Meningitis caused by susceptible strains of pneumococcus and meningococcus

250,000 units/kg/day divided in equal doses every 4 hours for 7 to 14 days depending on the infecting organism (maximum dose of 12 to 20 million units/day)

Disseminated Gonococcal infections (penicillin-susceptible strains)

weight less than 45 kg:


100,000 units/kg/day in 4 equally divided doses for 7 to 10 days


250,000 units/kg/day in equal doses every 4 hours for 10 to 14 days


250,000 units/kg/day in equal doses every 4 hours for 4 weeks

Arthritis, meningitis, endocarditis

weight 45 kg or greater: 10 million units/day in 4 equally divided doses with the duration of therapy depending on the type of infection

Syphilis (congenital and neurosyphilis) after the newborn period

200,000 to 300,000 units/kg/day (administered as 50,000 units/kg every 4 to 6 hours) for 10 to 14 days

Diphtheria (adjunctive therapy to antitoxin and for prevention of the carrier state)

150,000 to 250,000 units/kg/day in equal doses every 6 hours for 7 to 10 days

Rat-bite fever; Haverhill fever (with endocarditis caused by S. moniliformis)

150,000 to 250,000 units/kg/day in equal doses every 4 hours for 4 weeks

Renal Impairment

Penicillin G is relatively nontoxic, and dosage adjustments are generally required only in cases of severe renal impairment.

The recommended dosage regimens are as follows: Creatinine clearance less than 10 mL/min/1.73m2 ; administer a full loading dose (see recommended dosages in the tables above) followed by one-half of the loading dose every 8 to 10 hours.

Uremic patients with a creatinine clearance greater than 10 mL/min/1.73m2 ; administer a full loading dose (see recommended dosages in the tables above) followed by one-half of the loading dose every 4 to 5 hours.

Additional dosage modifications should be made in patients with hepatic disease and renal impairment.

For most acute infections, treatment should be continued for at least 48 to 72 hours after the patient becomes asymptomatic. Antibiotic therapy for Group A beta-hemolytic streptococcal infections should be maintained for at least 10 days to reduce the risk of rheumatic fever.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.

Preparation of Solution

Solutions of penicillin should be prepared as follows: Loosen powder. Hold vial horizontally and rotate it while slowly directing the stream of diluent against the wall of the vial. Shake vial vigorously after all the diluent has been added. Depending on the route of administration, use Sterile Water for Injection, USP or Sterile Isotonic Sodium Chloride Solution for Parenteral use.

Note: Penicillins are rapidly inactivated in the presence of carbohydrate solutions at alkaline pH.


The following table shows the amount of solvent required for solution of various concentrations:

Approx. Desired
Approx. Volume for
1,000,000 units (mL)
Solvent for Vial of
5,000,000 units (mL)
Infusion Only
20,000,000 units (mL)
















When the required volume of solvent is greater than the capacity of the vial, the penicillin can be dissolved by first injecting only a portion of the solvent into the vial, then withdrawing the resultant solution and combining it with the remainder of the solvent in a larger sterile container.

Penicillin G potassium for injection is highly water soluble. It may be dissolved in small amounts of Water for Injection, or Sterile Isotonic Sodium Chloride Solution for Parenteral Use. All solutions should be stored in a refrigerator. When refrigerated, penicillin solutions may be stored for seven days without significant loss of potency.

Buffered penicillin G potassium for injection may be given intramuscularly or by continuous intravenous drip for dosages of 500,000, 1,000,000 or 5,000,000 units. It is also suitable for intrapleural, intraarticular, and other local installations.


(1) Intramuscular Injection: Keep total volume of injection small. The intramuscular route is the preferred route of administration. Solutions containing up to 100,000 units of penicillin per mL of diluent may be used with a minimum of discomfort. Greater concentration of penicillin G per mL is physically possible and may be employed where therapy demands. When large doses are required, it may be advisable to administer aqueous solutions of penicillin by means of continuous intravenous drip.

(2) Continuous Intravenous Drip: Determine the volume of fluid and rate of its administration required by the patient in a 24-hour period in the usual manner for fluid therapy, and add the appropriate daily dosage of penicillin to this fluid. For example, if an adult patient requires 2 liters of fluid in 24 hours and a daily dosage of 10 million units of penicillin, add 5 million units of 1 liter and adjust the rate of flow so the liter will be infused in 12 hours.

(3) Intrapleural or Other Local Infusion: If fluid is aspirated, give infusion in a volume equal to 1/4 or 1/2 the amount of fluid aspirated, otherwise, prepare as for an intramuscular injection.

(4) Intrathecal Use: The intrathecal use of penicillin in meningitis must be highly individualized. It should be employed only with full consideration of the possible irritating effects of penicillin when used by this route. The preferred route of therapy in bacterial meningitides is intravenous, supplemented by intramuscular injection.

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