Potassium Chloride in Dextrose and Sodium Chloride
POTASSIUM CHLORIDE IN DEXTROSE AND SODIUM CHLORIDE- dextrose, sodium chloride and potassium chloride injection
B. Braun Medical Inc.
DESCRIPTION
(See chart below for quantitative information.)
Potassium Chloride in Dextrose and Sodium Chloride Injections USP are sterile, nonpyrogenic and contain no bacteriostatic or antimicrobial agents. These products are intended for intravenous administration.
The formulas of the active ingredients are:
Ingredients | MolecularFormula | MolecularWeight |
---|---|---|
Sodium Chloride USPPotassium Chloride USP | NaClKCl | 58.4474.55 |
Hydrous Dextrose USP | 198.17 |
Not made with natural rubber latex, PVC or DEHP.
The plastic container is made from a multilayered film specifically developed for parenteral drugs. It contains no plasticizers and exhibits virtually no leachables. The solution contact layer is a rubberized copolymer of ethylene and propylene. The container is nontoxic and biologically inert. The container-solution unit is a closed system and is not dependent upon entry of external air during administration. The container is overwrapped to provide protection from the physical environment and to provide an additional moisture barrier when necessary.
Composition – Each 100 mL contains: | |||||||||
---|---|---|---|---|---|---|---|---|---|
Solution | Hydrous Dextrose USP | Sodium Chloride USP | Potassium Chloride USP | Concentration of Electrolytes (mEq/liter) | Calories perliter | CalculatedOsmolaritymOsmol/liter | pH | ||
Sodium | Potassium | Chloride | |||||||
Water for Injection USP qs | |||||||||
0.15% Potassium Chloride in 5% Dextrose and0.20% Sodium Chloride Injection USP | 5 g | 0.2 g | 0.15 g | 34 | 20 | 54 | 170 | 360 | 4.4 (3.5–6.5) |
0.075% Potassium Chloride in 5% Dextrose and0.45% Sodium Chloride Injection USP | 5 g | 0.45 g | 0.075 g | 77 | 10 | 87 | 170 | 425 | 4.4 (3.5–6.5) |
0.15% Potassium Chloride in 5% Dextrose and0.45% Sodium Chloride Injection USP | 5 g | 0.45 g | 0.15 g | 77 | 20 | 97 | 170 | 445 | 4.4 (3.5–6.5) |
0.22% Potassium Chloride in 5% Dextrose and0.45% Sodium Chloride Injection USP | 5 g | 0.45 g | 0.22 g | 77 | 30 | 107 | 170 | 465 | 4.4 (3.5–6.5) |
0.30% Potassium Chloride in 5% Dextrose and0.45% Sodium Chloride Injection USP | 5 g | 0.45 g | 0.3 g | 77 | 40 | 117 | 170 | 490 | 4.4 (3.5–6.5) |
0.15% Potassium Chloride in 5% Dextrose and0.9% Sodium Chloride Injection USP | 5 g | 0.9 g | 0.15 g | 154 | 20 | 174 | 170 | 600 | 4.4 (3.5–6.5) |
Addition of medication should be accomplished using complete aseptic technique.
The closure system has two ports; the one for the administration set has a tamper evident plastic protector and the other is a medication addition site. Refer to the Directions for Use of the container.
CLINICAL PHARMACOLOGY
These intravenous solutions provide electrolytes and calories, and are a source of water for hydration. They are capable of inducing diuresis depending on the clinical condition of the patient.
Sodium, the major cation of the extracellular fluid, functions primarily in the control of water distribution, fluid balance, and osmotic pressure of body fluids. Sodium is also associated with chloride and bicarbonate in the regulation of the acid-base equilibrium of body fluid.
Potassium, the principal cation of intracellular fluid, participates in carbohydrate utilization and protein synthesis, and is critical in the regulation of nerve conduction and muscle contraction, particularly in the heart.
Chloride, the major extracellular anion, closely follows the metabolism of sodium, and changes in the acid-base balance of the body are reflected by changes in the chloride concentration.
Dextrose provides a source of calories. Dextrose is readily metabolized, may decrease losses of body protein and nitrogen, promotes glycogen deposition and decreases or prevents ketosis if sufficient doses are provided.
All MedLibrary.org resources are included in as near-original form as possible, meaning that the information from the original provider has been rendered here with only typographical or stylistic modifications and not with any substantive alterations of content, meaning or intent.
https://medlibrary.org/lib/rx/meds/potassium-chloride-in-dextrose-and-sodium-chloride-2/