Accidental ingestion of at least 50 mg of prazosin hydrochloride capsules in a two year old child resulted in profound drowsiness and depressed reflexes. No decrease in blood pressure was noted. Recovery was uneventful.
Should overdosage lead to hypotension, support of the cardiovascular system is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in the supine position. If this measure is inadequate, shock should first be treated with volume expanders. If necessary, vasopressors should then be used. Renal function should be monitored and supported as needed. Laboratory data indicate prazosin hydrochloride capsules are not dialysable because it is protein bound.
The dose of prazosin hydrochloride capsules should be adjusted according to the patient’s individual blood pressure response. The following is a guide to its administration:
1 mg two or three times a day (see WARNINGS).
Dosage may be slowly increased to a total daily dose of 20 mg given in divided doses. The therapeutic dosages most commonly employed have ranged from 6 mg to 15 mg daily given in divided doses. Doses higher than 20 mg usually do not increase efficacy, however a few patients may benefit from further increases up to a daily dose of 40 mg given in divided doses. After initial titration some patients can be maintained adequately on a twice daily dosage regimen.
When adding a diuretic or other antihypertensive agent, the dose of prazosin hydrochloride capsules should be reduced to 1 mg or 2 mg three times a day and retitration then carried out.
Concomitant administration of prazosin hydrochloride capsules with a PDE-5 inhibitor can result in additive blood pressure lowering effects and symptomatic hypotension; therefore, PDE-5 inhibitor therapy should be initiated at the lowest dose in patients taking prazosin hydrochloride capsules.
NDC: 68151-2030-1 1 CAPSULE in a BLISTER PACK
- Lubbe, WF, and Hodge, JV: New Zealand Med J, 94 (691) 169-172,1981.
- Davey, DA, and Dommisse, J: SA. Med J, Oct.4, 1980 (551-556).
Mylan Pharmaceuticals Inc.
Morgantown, WV 26505 U.S.A.
PRAZOSIN HYDROCHLORIDE CAPSULELabel Image
| PRAZOSIN HYDROCHLORIDE |
prazosin hydrochloride capsule
|Labeler — Carilion Materials Management (079239644)|
|Carilion Materials Management||079239644||REPACK (68151-2030)|
Revised: 12/2017 Carilion Materials Management
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