Prazosin Hydrochloride (Page 3 of 3)
OVERDOSAGE
Accidental ingestion of at least 50 mg of prazosin hydrochloride in a two year old child resulted in profound drowsiness and depressed reflexes. No decrease in blood pressure was noted. Recovery was uneventful.
Should overdosage lead to hypotension, support of the cardiovascular system is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in the supine position. If this measure is inadequate, shock should first be treated with volume expanders. If necessary, vasopressors should then be used. Renal function should be monitored and supported as needed. Laboratory data indicate prazosin hydrochloride is not dialyzable because it is protein bound.
DOSAGE & ADMINISTRATION
The dose of prazosin hydrochloride capsules should be adjusted according to the patient’s individual blood pressure response. The following is a guide to its administration:
Initial Dose
1 mg two or three times a day (see WARNINGS).
Maintenance Dose
Dosage may be slowly increased to a total daily dose of 20 mg given in divided doses. The therapeutic dosages most commonly employed have ranged from 6 mg to 15 mg daily given in divided doses. Doses higher than 20 mg usually do not increase efficacy, however a few patients may benefit from further increases up to a daily dose of 40 mg given in divided doses. After initial titration some patients can be maintained adequately on a twice daily dosage regimen.
Use With Other Drugs
When adding a diuretic or other antihypertensive agent, the dose of prazosin hydrochloride capsules should be reduced to 1 mg or 2 mg three times a day and retitration then carried out.
Concomitant administration of prazosin hydrochloride capsules with a PDE-5 inhibitor can result in additive blood pressure lowering effects and symptomatic hypotension; therefore, PDE-5 inhibitor therapy should be initiated at the lowest dose in patients taking prazosin hydrochloride capsules.
HOW SUPPLIED
Product: 50090-5695
NDC: 50090-5695-0 100 CAPSULE in a BOTTLE
NDC: 50090-5695-1 30 CAPSULE in a BOTTLE
REFERENCES
1) Lubbe, WF, and Hodge, JV: New Zealand Med J, 94 (691) 169-172,1981.
2) Davey, DA, and Dommisse, J: SA. Med J, Oct.4, 1980 (551-556).
PRAZOSIN HYDROCHLORIDE
Label Image PRAZOSIN HYDROCHLORIDE prazosin hydrochloride capsule | ||||||||||||||||||||||||||||
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Labeler — A-S Medication Solutions (830016429) |
Establishment | |||
Name | Address | ID/FEI | Operations |
A-S Medication Solutions | 830016429 | RELABEL (50090-5695), REPACK (50090-5695) |
Revised: 12/2023 A-S Medication Solutions
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