Skyrizi (Page 9 of 13)

INSTRUCTIONS FOR USE
SKYRIZI® (sky-RIZZ-ee)
(risankizumab-rzaa)
injection, for subcutaneous use 150 mg/mL prefilled syringe

Read Before First Use

Refer to the Medication Guide for product information.

SKYRIZI Single-Dose Prefilled Syringe

SKYRIZI Single-Dose Prefilled Syringe
(click image for full-size original)

Important Information

  • Keep SKYRIZI in the original carton to protect from light until time to use.
  • The liquid should look clear to yellow and may contain tiny white or clear particles.
  • Do not use SKYRIZI if the liquid is cloudy or contains flakes or large particles.
  • Do not use SKYRIZI if the expiration date (EXP:) shown on the carton and prefilled syringe has passed.
  • Do not use SKYRIZI if the liquid has been frozen (even if thawed).
  • Do not shake SKYRIZI.
  • Do not use SKYRIZI if the prefilled syringe has been dropped or damaged.
  • Do not use SKYRIZI if carton perforations are broken. Return product to the pharmacy.
  • Do not remove the needle cover until right before giving the injection.

Keep SKYRIZI and all medicines out of the reach of children.

Please Read Complete Instructions for Use Before Using SKYRIZI Prefilled Syringe

Before Injecting

  • Receive training on how to inject SKYRIZI before giving injection. Call your healthcare provider or (866) SKYRIZI or (866) 759-7494 if you need help.
  • Mark your calendar ahead of time to remember when to take SKYRIZI.
  • Leave the carton at room temperature and out of direct sunlight for 15 to 30 minutes to warm.
    Do not remove the syringe from the carton while allowing SKYRIZI to reach room temperature.
    Do not warm SKYRIZI in any other way (for example, do not warm it in a microwave or in hot water).

Important Information

  • The liquid should look clear to yellow and may contain tiny white or clear particles.
  • Do not use SKYRIZI if the liquid is cloudy or contains flakes or large particles.
  • Do not use SKYRIZI if the expiration date (EXP:) shown on the carton and prefilled syringe has passed.
  • Do not use SKYRIZI if the syringe has been dropped or damaged.
  • Do not use SKYRIZI if carton perforations are broken. Return product to the pharmacy.

Storage Information

  • Store SKYRIZI in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • Do not shake SKYRIZI.
  • Keep SKYRIZI in the original carton to protect from light until time to use.
  • SKYRIZI is not made with natural rubber latex.
  • Do not use if the liquid has been frozen (even if thawed).

Keep SKYRIZI and all medicines out of the reach of children.

Call your healthcare provider or (866) SKYRIZI or (866) 759-7494 if you need help or do not know how to proceed.

Step 1Gather the supplies for the injection.
  • Do not hold or pull the plunger rod when removing the prefilled syringe from the sleeve.
Place the following on a clean, flat surface:
  • 1 prefilled syringe (included)
  • 1 alcohol swab (not included)
  • 1 cotton ball or gauze pad (not included)
  • FDA-cleared sharps disposal container (not included). See “Used SKYRIZI Prefilled Syringe Disposal ” for information on how to throw away (dispose of) used prefilled syringes.
Wash and dry your hands.
Step 2Remove prefilled syringe from cardboard sleeve by holding the finger grip.
Step 3Pick from the 3 injectable areas:
  • Front of left thigh or right thigh
  • Your abdomen (belly) at least 2 inches from your navel (belly button)
Wipe the injection site in a circular motion with the alcohol swab before the injection.
  • Do not touch or blow on the injection site after it is cleaned. Allow the skin to dry before injecting.
  • Do not inject through clothes.
  • Do not inject into skin that is sore, bruised, red, hard, scarred, or has stretch marks, or into areas affected by psoriasis.
Step 4Hold the prefilled syringe with covered needle facing down, as shown. Check the liquid in the prefilled syringe.
  • It is normal to see 1 or more bubbles in the window.
  • The liquid should look clear to yellow and may contain tiny white or clear particles.
  • Do not use the prefilled syringe if the liquid is cloudy or contains flakes or large particles.
Step 5Remove the needle cover.
  • Hold the prefilled syringe in 1 hand between the finger grip and needle cover.
  • With the other hand, gently pull the needle cover straight off.
  • Do not hold or pull the plunger rod when removing the needle cover.
  • You may see a drop of liquid at the end of the needle. This is normal.
  • Throw away the needle cover.
  • Do not touch the needle with your fingers or let the needle touch anything.
Step 6Hold the body of the prefilled syringe in 1 hand between the thumb and index fingers. P inch the area of cleaned skin with your other hand and hold it firmly. Insert the needle into the skin at about a 45-degree angle using a quick, short movement. Hold angle steady.
Step 7Slowly push the plunger rod all the way in until all of the liquid is injected, and the prefilled syringe is empty. Pull the needle out of the skin while keeping the prefilled syringe at the same angle. Release the plunger rod and allow the prefilled syringe to move up until the entire needle is covered by the needle guard. The prefilled syringe needle guard will not activate unless all the liquid has been injected.
  • Press a cotton ball or gauze pad over the injection site and hold for 10 seconds.
  • Do not rub the injection site. You may have slight bleeding. This is normal.
Step 8Put your used prefilled syringe in a FDA-cleared sharps disposal container right away after use.
  • Do not throw away (dispose of) the used prefilled syringe in the household trash.
For more information, see “Used SKYRIZI Prefilled Syringe Disposal” section.

Questions About Using SKYRIZI

Q.What if I need help on how to inject SKYRIZI?
A.Call your healthcare provider or (866) SKYRIZI or (866) 759-7494 if you need help.
Q.What should I do with the used prefilled syringe after my injection?
A.Throw away (dispose of) the used prefilled syringe in a sharps disposal container and not your household trash. You can sign up to receive sharps containers for SKYRIZI syringe disposal at no additional cost by going to www.SKYRIZI .com or calling (866) SKYRIZI or (866) 759-7494.
Q.How do I know when the injection is complete?
A.The injection is complete when the prefilled syringe is empty, the plunger rod is pushed all the way in, and the syringe needle guard is activated.

Used SKYRIZI Prefilled Syringe Disposal

If you do not have a FDA-cleared sharps disposal container, you may use a household container that is:

  • made of a heavy-duty plastic,
  • can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
  • upright and stable during use,
  • leak-resistant, and
  • properly labeled to warn of hazardous waste inside the container.

When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes.

For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: www.fda.gov/safesharpsdisposal.

Do not recycle your used sharps disposal container.

Manufactured by: AbbVie Inc., North Chicago, IL 60064, U.S.A.
US License Number 1889
SKYRIZI® is a registered trademark of AbbVie Biotechnology Ltd.
© 2019-2022 AbbVie Inc.
20071033 R1

This Instructions for Use has been approved by the U.S. Food and Drug Administration.

Revised: 03/2022

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