SYMJEPI (Page 5 of 6)


Instructions for Use

SYMJEPI (sim-JEP-ee) (epinephrine injection, USP) 0.3 mg prefilled syringe

For Allergic Emergencies (anaphylaxis)

Read this Instructions for Use carefully before you use this product.

Before you need to use your SYMJEPI syringe make sure your healthcare provider shows you the right way to use it. Parents, caregivers, and others who may be in a position to administer SYMJEPI should also understand how to use it. If you have questions, ask your healthcare provider.

Get Ready to Use SYMJEPI

SYMJEPI works like a standard prefilled syringe.


SYMJEPI is injected downwards, into the thigh, while sitting (as shown), through clothing if necessary.


Ready to Use SYMJEPI


When ready to inject, pull off cap to expose needle.


DO NOT put finger on top of the device.

If you are administering SYMJEPI to a young child, hold the leg firmly in place while administering the injection.

Hold SYMJEPI by finger grips only and slowly insert the needle into the thigh.



After needle is in thigh: Push the plunger all the way down until it clicks and hold for 2 seconds.


Remove the syringe and massage the injection area for 10 seconds.

Get Help

Get emergency medical help now.


Tell healthcare provider that you received an injection of epinephrine.

Use second syringe if necessary


You may need a second SYMJEPI syringe if symptoms continue or recur.

IFU 10

SYMJEPI is a single use prefilled syringe that delivers a fixed dose of epinephrine. The prefilled syringe cannot be reused. It is normal for most of the medicine to remain in the syringe after the dose has been injected.

The correct dose has been injected if the plunger has been pushed all the way down and the solution window is at least partially blocked.

If you will be administering SYMJEPI to a young child, ask your healthcare provider to show you how to properly hold the leg in place while administering a dose.

After use and Disposal — Hold SYMJEPI with one hand with your fingers behind the needle and slide the safety guard over the needle until it clicks. Put the used syringe into the grey case and close the case.

  • Take the case with the used syringe with you when you go to see a healthcare provider.
  • Tell the healthcare provider that you have received an injection of epinephrine. Show the healthcare provider where you received the injection.
  • Give your used SYMJEPI syringe to your healthcare provider for inspection and proper disposal.

​After Use

Safety Guard

Safety Guard

Using one hand with fingers behind the needle slide safety guard over needle.

For more information see Patient Information sheet or ask your healthcare provider.

How to Store — Keep SYMJEPI in its plastic case nearby and ready for use at all times.

  • Store at room temperature, between 68°F to 77°F (20°C to 25°C). Do not expose to extreme cold or heat. For example do not store in your vehicle’s glove box and do not store in the refrigeration or freezer.
  • Store the SYMJEPI syringe in its closed plastic case to protect from light.

Check Your SYMJEPI Periodically The solution should be clear when viewed through the window on the device. If the solution is discolored (pinkish or brown color), cloudy or contains particles, replace the SYMJEPI with a new one.

Your SYMJEPI Has an Expiration Date — Example Dec 18 = December 31, 2018. Replace SYMJEPI before the expiration date. Dispose of expired SYMJEPI properly by taking the SYMJEPI in its case to a healthcare provider or hospital emergency room.

For more information about SYMJEPI prefilled syringe and proper use of the product, call 1-858-997-2400 or visit

This Instructions for Use has been approved by the U.S. Food and Drug Administration.

SYMJEPI is a registered trademark of Adamis Pharmaceuticals Corporation.

Manufactured for Adamis Pharmaceuticals, San Diego, CA 92130, USA. Approved: June 2017


(epinephrine injection, USP) 0.3 mg pre-filled syringe

Instructions for Use

Pull out and Read before Use

Rx Only


Syringe Label

Syringe Label
(click image for full-size original)


Epinephrine Injection

0.3 mg

Lot: Exp:

Distributor: Adamis Pharmaceuticals

Replace when discolored or expired

[2] Insert Needle in Thigh

After use Call 911

Syringe Case Label

Syringe Case Label
(click image for full-size original)

​injection 0.3 mg

Prefilled Syringe

Remove Device From Case

1 Pull off cap
2 Insert in thigh
3 Push plunger

Pull latch to open

How to Store
Store SYMJEPI in case at room temp. between 68° to 77°F. DO NOT store in refrigerator or hot cars.

Read your Instructions for Use carefully before use.

Check Solution

If solution is discolored, replace your SYMJEPI.

RX only

ADAMIS Pharmaceutical Corporation

NDC 38739-200-01



2-Pack Inner Carton

2-Pack Inner Carton
(click image for full-size original)

NDC #38739-200-02



(epinephrine) Injection 0.3 mg



Protect from light. Store at room temperature.

USP (0.3mg/ 0.3mL)

Contains Two Syringes

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