Tetrofosmin

TETROFOSMIN — tetrofosmin injection, powder, lyophilized, for solution
AnazaoHealth Corporation

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Dear Medical Professional,

Per your order, we have compounded Tetrofosmin as a sterile, freeze-dried preparation in a 10 mL vial. The characteristics of this preparation are described below.

DESCRIPTION

AnazaoHealth’s compounded Tetrofosmin vial is a sterile, non-pyrogenic preparation that consists of a lyophilized mixture of 0.35 mg of Tetrofosmin, 1.5 mg of D-Gluconate, 0.03 mg of Stannous Chloride Dihydrate, 0.48 mg of Disodium Sulphosalicylate, and 2.7 mg of Sodium Hydrogen Carbonate and is maintained under an inert nitrogen atmosphere. It contains no antimicrobrial preservative.

INDICATIONS

Tetrofosmin is a diagnostic agent used to assess areas of reversible myocardial ischemia in the presence or absence of infracted myocardium and is also used to assess ventricular function.

PHYSICAL HALF-LIFE & TARGET ORGANS

The physical half-life of technetium, Tc99m, is 6 hours and has a principal radiation emission of gamma photons with a mean energy of 140 KeV.

Estimated Absorbed Radiation Dose (Technetium Tc99m Tetrofosmin Injection)
Absorbed radiation dose
Exercise Rest
Target organ rad/mCi µGy/MBq rad/mCi µGy/MBq
Gall bladder wall 0.123 33.2 0.180 48.6
Upper large intestine 0.075 20.1 0.113 30.4
Bladder wall 0.058 15.6 0.071 19.3
Lower large intestine 0.057 15.3 0.082 22.2
Small intestine 0.045 12.1 0.063 17.0
Kidney 0.039 10.4 0.046 12.5
Salivary glands 0.030 8.04 0.043 11.6
Ovaries 0.029 7.88 0.035 9.55
Uterus 0.027 7.34 0.031 8.36
Bone surface 0.023 6.23 0.021 5.58
Pancreas 0.019 5.00 0.018 4.98
Stomach 0.017 4.60 0.017 4.63
Thyroid 0.016 4.34 0.022 5.83
Adrenals 0.016 4.32 0.015 4.11
Heart wall 0.015 4.14 0.015 3.93
Red marrow 0.015 4.14 0.015 3.97
Spleen 0.015 4.12 0.014 3.82
Muscle 0.013 3.52 0.012 3.32
Testes 0.013 3.41 0.011 3.05
Liver 0.012 3.22 0.015 4.15
Thymus 0.012 3.11 0.009 2.54
Brain 0.010 2.72 0.008 2.15
Lungs 0.008 2.27 0.008 2.08
Skin 0.008 2.22 0.007 1.91
Breasts 0.008 2.22 0.007 1.83

Dose calculations were performed using the standard MIRD method (MIRD Pamphlet No.1 (rev),Society of Nuclear Medicine, 1976).

Effective dose equivalents (EDE) were calculated in accordance with ICRP 53 (Ann. ICRP 18 (1-4),1988) and gave values of 8.61 × 10-3 mSV/MBq and 1.12 × 10-2 mSV/MBq after exercise and rest, respectively.

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